Plant-Derived Antiviral Chewing Gum as a Novel Oral Intervention Against Respiratory and Herpes Viruses

Abstract

Plant-derived antiviral chewing gum has emerged as a promising oral intervention for reducing the transmission of respiratory and herpes viruses. The oral cavity acts as a major reservoir for viral replication and dissemination, particularly in infections caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), herpes simplex virus (HSV), and influenza viruses. Recent studies have demonstrated that plant-derived bioactive compounds, including lectins, polyphenols, and flavonoids, possess potent antiviral properties by disrupting viral envelopes, inhibiting viral attachment, and suppressing viral replication.

The incorporation of these bioactive compounds into chewing gum formulations enables prolonged retention within the oral cavity, thereby increasing mucosal exposure and enhancing localized antiviral activity. This review evaluates the mechanisms of action, therapeutic applications, and public health significance of plant-derived antiviral chewing gum. Evidence from preclinical and early translational studies indicates that these formulations may significantly reduce salivary viral load and decrease viral transmission.

Although current findings are encouraging, further clinical investigations are required to establish long-term safety, optimal dosage, and therapeutic efficacy. Plant-derived antiviral chewing gum may serve as a valuable adjunct to existing preventive strategies, including vaccination, masking, and hygiene measures.